![]() On the other hand, 124 (14%) of 892 nonallergic children met the criteria for a possible allergic reaction to propofol. Sommerfield found that two of 304 children with egg, peanut, soybean, or legume allergy experienced a possible allergic reaction to propofol that may be due to egg sensitization in children sensitized to both egg yolk and egg white. Among egg-allergic children, reactions to propofol was reported in a child with egg anaphylaxis but not in those with egg allergy. The use of propofol in children with egg and soy allergy is a matter of debate. Propofol is a fat emulsion containing soybean oil and purified egg lecithin (phospholipids derived from egg yolk). Propofol is an intravenous anesthetic that is widely used for the induction and maintenance of anesthesia as well as for endoscopic and pediatric sedation. If the skin test result is positive, the vaccine can be given in graded doses in a hospital. If the test result is negative, vaccination can be given with a 60-min observation following the injection. Yellow fever vaccine contains egg protein and children with egg allergy should receive a skin prick test to the vaccine with progressive dilution (1:10 and 1:1) and an intradermal test with a 1:100 dilution. Children with a previous history of immediate allergic reactions to egg that do not involve only skin (anaphylaxis) should receive the influenza vaccine under the supervision of personnel who are experts in recognizing and treating allergic reactions. The children should then be kept under medical surveillance for 30 min. Both inactivated influenza vaccine (IIV) and live attenuated influenza vaccine can be safely administered to children with egg allergy in the usual manner. However, there is no additional risk for children with severe egg allergy. ![]() This method theoretically could lead to higher egg protein in the vaccine. Īllergic reactions to the influenza vaccine in children with egg allergy was a matter of debate since this vaccine cultured on embryonated chicken eggs. Children who are allergic to eggs can safely receive both types of vaccines without any precautions. They both contain little or no egg protein. ![]() ![]() Chick embryo fibroblast cultures are used for measles-mumps-rubella and purified chick embryo rabies vaccines. Vaccines prepared on embryonated chicken eggs can contain trace amounts of egg proteins, especially ovalbumin. ![]()
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